Research Investigator (In-vitro/Cellular Pharmacologist) Job Opportunity

Isomorphic Labs, a visionary Alphabet company, is at the forefront of revolutionizing drug discovery with a computational and AI-first approach. We are dedicated to accelerating the pace, enhancing the efficacy, and reducing the costs associated with drug discovery. Join us in pioneering the 'digital biology' era, aiming to create a transformative social impact for millions globally.

Join Our Dynamic Team

Be part of a multidisciplinary team fostering innovation and contribute meaningfully to our ambitious goals. Experience an inspiring, collaborative, and entrepreneurial culture at Isomorphic Labs.

Your Impact

Isomorphic Labs seeks exceptional individuals for a significant role within our in-vitro pharmacology sub-team, part of the translational science department. This role is ideal for experienced pharmacologists skilled in biophysical, biochemical, and cellular assays, contributing in-vitro expertise to drug discovery projects.

This opportunity allows you to collaborate with world-leading AI, ML, and drug discovery experts, developing novel ways to test biological hypotheses. You'll create a deep mechanistic understanding of drug-target interactions and play a pivotal role in advancing our oncology, immunology, and partnership portfolios from early drug discovery to clinical phases.

Key Responsibilities

• Design comprehensive biological screening cascades for internal and partnered drug design programs.
• Collaborate with CROs to design experiments, ensuring high-quality biological data to inform clinical pathways.
• Provide expertise to AI/ML teams in developing leading models of biological systems.
• Translate biological data into insights for project teams and ML research.
• Lead or integrate into projects, providing strategic input to ensure success.
• Contribute to regulatory documentation for preclinical and clinical work.
• Work cross-functionally with Drug Design and Technology teams.

Required Skills and Qualifications

• BSc, MSc, or PhD in a relevant biology field.
• Extensive experience in biological screening cascades for drug design across various phases.
• In-depth knowledge of in-vitro, biophysical, or cellular assay techniques like ELISA, HTRF, FP, and more.
• Proficiency in protein expression/purification techniques.
• Experience interpreting data from diverse assay types.
• Knowledge of working with CROs to acquire and interpret high-quality biological data.
• Ability to phase in-vitro pharmacology activities collaboratively with stakeholders.
• Focused and goal-oriented approach to candidate delivery.
• Dynamic, flexible individual able to work across multiple projects and therapeutic areas.
• Collaborative mentality to drive shared learning across teams.
• Effective communication skills across interdisciplinary teams.

Preferred Skills

• Experience in project leadership or biology domain leadership within drug discovery programs.
• Collaborated with Data Science groups for biological data ingestion systems.
• Expertise in compound management.
• Contributions to projects delivering clinical candidates.
• Designing and implementing assays for alternative modalities or chemistries.
• Understanding of medicinal chemistry concepts.
• Knowledge of machine learning models applied to biological systems.
• Experience with multiple biological mechanisms, disease indications, and administration routes.

Our Culture and Values

Success at Isomorphic Labs requires a shared commitment to our values:

• Thoughtful: Embracing curiosity, creativity, and rigorous science.
• Brave: Displaying fearlessness, initiative, and integrity.
• Determined: Pursuing our goals with urgency, confidence, and agility.
• Together: Emphasizing connection, collaboration, and impactful relationships.

Creating an Inclusive Company

We aim for our teams to reflect the diverse populations we serve, fostering an inclusive environment where collaboration and shared learning thrive. We're committed to equal employment opportunities and welcome applicants regardless of sex, race, religion, ethnic origin, disability, age, citizenship, marital status, sexual orientation, gender identity, or pregnancy. Should you require accommodations,