Join Tango Therapeutics as Associate Director of Clinical Data Management

Company Overview

Tango Therapeutics is a cutting-edge biotechnology company focused on discovering novel drug targets and delivering next-generation precision medicine for cancer treatment. Leveraging the genetic principle of synthetic lethality, Tango aims to develop therapies that target critical areas in oncology, including tumor suppressor gene loss and the ability of cancer cells to evade immune cell killing. Our labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Job Summary

As the Associate Director of Clinical Data Management at Tango Therapeutics, you will report to the Vice President of Biometrics. You will lead the clinical data management processes across Tango’s clinical trials, from planning through data generation to database lock. This role involves implementing best practices, managing data management vendors, and ensuring data handling efficiency.

Your Role

• Manage clinical data management partnerships with clinical CROs for Tango’s clinical trials.
• Provide oversight for fully outsourced clinical data management activities from RFP to final database lock, collaborating effectively with CRO partners to standardize data handling plans, data transfer specifications, metrics, and data review tools.
• Develop and/or write database designs, edit checks, CRF completion guidelines, and Data Management Plans for in-house activities, ensuring CDASH and SDTM standards.
• Work with cross-functional team members to standardize data collection and reporting.
• Collaborate with internal and external functions (e.g., CROs, software vendors, clinical development partners) to meet project timelines and goals efficiently and within budget.
• Attend study team meetings to provide updates and resolve issues related to data collection and analysis.
• Work collaboratively to ensure clinical data readiness for early-phase deliverables.
• Support the Tango eCRF library and database build configuration.
• Perform additional duties and responsibilities as required.

What You Bring

• Bachelor’s degree in computer science or a science-based subject, with at least 8 years of clinical data management experience in the industry, covering various indications and EDC platforms.
• At least three years of management experience in a clinical research environment, preferably across multiple therapeutic areas including oncology.
• Strong experience in vendor management and oversight.
• Solid technical skills across data platforms; programming experience is preferred.
• Experienced in designing clinical trials using CDASH and SDTM standard terminology.
• Proficient in cross-functional collaboration with other related roles such as Biostatistics, Statistical Programming, and Pharmacovigilance.
• Understanding of FDA and ICH GCP guidelines to ensure proper reporting of clinical trial data.
• Experience in regulatory GCP inspections/audits is preferred.
• Familiarity with data visualization software such as Spotfire and eluminate.
• Ability to manage multiple projects in a fast-paced environment.

We are an equal opportunity employer and value diversity at our company. We do not discriminate based on race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Company: Tango Therapeutics

Job Title: Associate Director, Clinical Data Management