Join Bicycle Therapeutics as a Senior Translational Data Scientist

Company Description:

Bicycle Therapeutics is a clinical-stage biopharmaceutical company pioneering a novel class of medicines known as Bicycle^® molecules that target diseases underserved by current therapeutics. These synthetic short peptides, designed with small molecule scaffolds to form two loops, stabilize their structural geometry for high affinity and selectivity in target binding. Our key clinical trials include:

• BT8009: A Bicycle^® Toxin Conjugate (BTC^®) targeting Nectin-4.
• BT5528: A BTC targeting EphA2.
• BT7480: A Bicycle Tumor-Targeted Immune Cell Agonist^® (Bicycle TICA^®) targeting Nectin-4 and CD137.

We are also developing Bicycle^® Radio Conjugates (BRC™) for radiopharmaceutical applications and exploring other therapeutic applications via various partnerships.

Headquartered in Cambridge, UK, with additional key functions in Cambridge, MA, Bicycle Therapeutics actively promotes a culture of adventure, dedication, and teamwork.

Our Values:

• Adventurous: Delivering extraordinary results for our patients.
• Dedicated to Our Mission: Driving change through determination.
• One Team: Succeeding together as a cohesive unit.

Job Description:

We are seeking a Senior Translational Data Scientist with robust software engineering, data analytics skills, and an oncology background to advance our Translational Sciences team. You will lead the development and maintenance of a biomarker software solution to support our clinical-stage oncology assets.

Key Responsibilities:

• Lead the development and customization of biomarker software for clinical-stage oncology assets.
• Manage data ingestion, integration, and visualization efforts for our targeted toxin and immune-oncology programs.
• Oversee external scientists/programmers and develop integrated non-clinical/clinical biomarker databases.
• Migrate internal R-scripts and Shiny apps into the software solution.
• Provide platform training and support to Bicycle scientists.
• Support data management of preclinical and clinical datasets (e.g. Nanostring, NGS).
• Integrate relevant datasets for reverse translation analytics, developing clear analyses and visualizations.
• Collaborate in a cross-functional environment, effectively communicating with project teams.
• Document data transfer specs, R scripts, and data analysis processes.

Qualifications:

Essential:

• Experience with clinical biomarker software solutions.
• Proficient in coding (R preferred) for data ingestion, wrangling, integration, and analysis.
• Strong software engineering skills, familiarity with AWS, Posit, and Gitlab.
• Strong bioinformatics skills, including sequencing data analysis.
• Experience with oncology-focused biomarker datasets.
• Proactive in a fast-paced environment. Team player, conscientious, organized, and creative.

Desirable:

• Experience with EDC and/or biomarker data from clinical trials.
• Familiarity with LSAF.

Additional Information:

Benefits:

• State-of-the-art campus with on-campus restaurant and Montessori nursery.
• Flexible working environment.
• Competitive rewards, including an annual company bonus.
• Employee recognition schemes.
• 28 days annual leave plus bank holidays, with optional additional 5 days.
• Employer-contributed pension without mandatory employee contribution.
• Life assurance cover at 4x basic salary.
• Private Medical Insurance covering optical and dental care.
• Enhanced parental leave policies.
• Group income protection.